For correspondence: Yuliya Vladimirovna Mirolyubova, 2 Akkuratova str. Clinical oncohematology. Flow cytometry is successfully used for diagnosis of malignant lymphoproliferative disorders. However, there are atypical cases that are difficult to interpret; thus, new markers relevant for the differential diagnosis are to be searched for.
The paper presents experience in following up and treating hairy cell leukemia HCL during pregnancy. The combination of HCL and pregnancy was observed in 5 patients. The diagnosis of HCL was based on a conventional examination protocol: clinical blood analysis with the morphological assessment of lymphocytes, a myelogram and trepanobiopsy, immunophenotypic analysis of lymphocytes or bone marrow in all the patients , cytochemical determination of tartrate-resistant acid phosphatase in 3 patients, and identification of BRAFVE mutation in 3 patients. Three pregnant women were treated for HCL in the postpartum period.